Get Rid of Your Gas, Bloating, Indigestion and Reflux for Good, with Clinical Strength Zygest Digestive Enzymes
Plus, Save Money with Discounts, Free Shipping and More!
Braxton Ponder, L.Ac.
Board Certified Herbalist
Licensed Acupuncturist
Pagosa Springs, Colorado
I know you are tired of suffering after every meal, and long to enjoy your favorite foods again, without the bloating, indigestion, pain and discomfort that comes from poor digestion. You may know that adequate digestive enzymes are critical to trouble-free digestion, but don't know how to determine which product you need, what brands to trust for reliable quality, and which gives you the best value for your money.
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Why Do I Need Enzymes?
Digestive enzymes are naturally occurring substances that enhance or speed up the biochemical digestive processes in the body. We produce a variety of specialized enzymes at various levels of our digestive tract, starting with the saliva in our mouths, and continuing on with different enzymes along the way down into our intestines. Each enzyme is intended to help break down a specific food type, such as fat, carbs, or protein, the lactose in milk, or the cellulose contained in many vegetables.
Some people have deficiencies in specific enzymes, resulting in problems digesting particular food types. And over the years, most of us will produce fewer digestive enzymes overall, resulting in deficient digestion and a multitude of symptoms you probably recognize: bloating and abdominal distension, gas and indigestion, and even the development of food sensitivities.
What Makes Zygest Special?

Zygest by Physiologics is a specialized blend of
digestive enzymes that can be easily added into many
types of diets and nutritional plans. The formula
contains a broad spectrum of enzymes essential to the
proper digestion of nutrients. It is designed to offer
support at multiple points in the digestive process,
including the fundus and antrum of the gastric region,
as well as the duodenum and other areas of the small
intestine. Further along on this page you can read about
the function and purpose of each ingredient included in
Zygest.
An Important Note on Quality:
Enzyme strength is measured in terms of their actual activity. A product that contains a boatload of enzymes but unless they are proven to be functional, they are useless. The familiar weight measurement of mg is virtually meaningless when it comes to enzymes. Here, the most important measurement is the activity and potency. Product labels should list enzyme strength in standard activity units rather than by weight. To measure activity of digestive enzymes, they are tested for the quantity of digestion that occurs under specific conditions. The results are reported in Food Chemical Codex (FCC) units, and those units (there are different unit scores for each enzyme type) should be on your product label.
The Zygest® enzyme blend is processed through the National Enzyme Company, which is the leader in nutritional enzyme technology. You can see that all the digestive enzymes are labeled according to activity units, and are certified by a Quality Control specialist based on the regulations set forth in the Food and Chemical Codex.*
- Zygest uses a form of digestive enzymes studied in scientific gastrointestinal models and certified through FCC standards.*
- Provides gastric support for all types of nutritional plans, whether they are low or high carbohydrate, fat and protein.*
- Gives multi-level support by supplying 10 distinct digestive enzymes.*
- All enzymes are formulated from vegetarian sources.*
Jump Down to the Clinical Evidence Section
About the Company
Physiologics vitamins and supplements have long been a favorite in my clinic, and with good reason: these are professional quality products sold exclusively through licensed health care practitioners. Some companies say they are “Doctor Recommended” when a doctor on their payroll says they like the products. With Physiologics, you know you are buying supplements consistently recommended by thousands of doctors over the last 17 years!
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Zygest® is a registered dietary supplement with the United States Patent and Trademark office. This specialized formulation contains a broad spectrum of protein, carbohydrate, and fat-digesting enzymes to promote digestion of nutrients. Zygest® is designed to offer support at various levels including digestion occurring in the fundus and antrum of the gastric region, as well as digestion taking place in the duodenum and other areas of the small intestine. Enzymes are formulated to reflect activity levels as certified by a Quality Control specialist, utilizing standards set through the Food and Chemical Codex (FCC).*
Enzyme Structure and Functions
Zygest® contains multiple enzymes designed to serve as biological catalysts for the breakdown of macronutrients.*
Amylase is an enzyme that is naturally secreted by pancreatic cells in-vivo. Release of this enzyme is stimulated by carbohydrate containing foods. Once released, amylase can biochemically react with digestion products such as starches and glycogen to form di- and trisaccharides through hydrolysis. The amylase within Zygest® is certified in dextrinizing units, which is defined as the quantity of alpha-amylase that will dextrinize soluble starch in the presence of excess beta-amylase.*
Protease is an enzyme designed to assist in protein digestion. Protein digestion begins in the gastric region when splitting occurs at nitrogen bonds to form products such as proteoses, peptones, and large polypeptides. Digestion continues with pancreatic enzymes of the upper small intestine and with the epithelial cells of the small intestinal wall. Zygest® contains Proteases standardized through both Hemoglobin Unit of Tyrosine Basis (HUT’s) and Spectrophotometric Acid Protease Units (SAPU’s), two different measures of protein digestion.*
Lipase is another naturally occurring enzyme which helps digest fat, and can be found in-vivo in the pancreas and epithelial cells of the small intestine. Fat digestion is a multi-level process which includes emulsification to decrease the interfacial tension of the fat globule surface. Once this is achieved, enzymes such as lipase can then help split fat into monoglycerides and fatty acids. Zygest® contains Lipase which is certified through Lipase Units, which is based on digestion of a standard olive oil substrate.*
Lactase is a specialized enzyme designed to split lactose disaccharides into glucose and galactose monosaccharides. Lactase is naturally found in the microvilli of the brush border of the epithelial cells. Once lactose digestion occurs, glucose and galactose are immediately absorbed into the portal blood. The lactase in Zygest® is certified through Acid Lactase Units (ALU’s), which is a measure of its ability to liberate o-nitrophenol per conditions of the assay.*
Both Bromelain and Papain are added for their protein digestibility scores. Each is certified through Papain Units as defined by the FCC. Papain Units measure tyrosine liberation per hour under the specific conditions of the assay.*
Cellulase and Hemicellulase round out the Zygest® formula. Cellulase is certified through Cellulase Units, which measure the quantity of enzyme required to produce a relative fluidity change of 1 in 5 minutes of a standard cellulose solution. Hemicellulase is certified through Hemicellulase Units per FCC regulations, which is the amount of enzyme required that will produce a relative fluidity change of 1 over a period of 5 minutes in a locust bean gum substrate under specific assay conditions.*
Applications
For clients seeking a premier digestive enzyme supplement that contains a broad-spectrum of enzymes and activity, Zygest® is an excellent choice.* Zygest® can be orally administered regardless of the meal composition or nutritional plan, due to its diverse enzyme preparation.
Clinical Evidence
A digestion study was conducted by The Netherlands Organisation for Applied Scientific Research. The experimental protocol was conducted with a computer controlled dynamic gastrointestinal model (TIM). TIM is a patented technology designed to stimulate the conditions of the human stomach and small intestine and allows for sampling at various stages to obtain real time data. Results found that adding digestive enzymes, as found in Zygest®, promoted digestion of carbohydrates as compared to digestion without additional digestive enzymes. Results also found that digestion of proteins in the ileum was positively supported as compared to digestion without added enzymes.
A second digestion study was conducted by the same research group, this time using a model that simulated conditions when digestion would be significantly reduced. Results found that adding digestive enzymes promoted digestion of carbohydrates and proteins compared to digestion without enzymes. These results were obtained through samples taken at the level of the jejunum and ileum. Based on the results of both studies, the researchers concluded that enzymes from the National Enzyme Company (suppliers of ygest®) can be used to support digestion.
Suggested Dosage
Take one (1) to two (2) capsules up to three times daily with meals or follow the advice of your health care professional. As a reminder, discuss the supplements and medications you take with your health care providers.