Nutritionally Supports Sound Sleep*

(Available as a liquid, as well as 1mg, 3mg & 5mg Tabs)

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ALSO KNOWN AS: n-Acetyl-5-Methoxytryptamine

PRODUCT DISCUSSION
Clinical trials involving orally supplemented melatonin have implicated this indoleamine to have positive metabolic interactions on various sleep parameters. Physiologic’s supplies Melatonin at dosage levels consistent with published research which demonstrates its ability to promote calm, restful sleep.* This special formulation provides high-dosage melatonin for those who may need extra support for the pineal gland and other brain regions such as the suprachiasmatic nucleus and pars tuberalis.* Melatonin may also prove to be useful for frequent travelers experiencing jet lag.*

STRUCTURE AND FUNCTION
The pineal gland is the organ where information about light and dark is processed and then relayed to cells throughout the body. The eyes deliver information to the pineal gland through different routes that include the retinohypothalamic tract and the suprachiasmatic nuclei. Norepinephrine released from postganglionic nerve endings to the pineal gland helps control melatonin release. This release of norepinephrine to the pinealocytes occurs at night, which is when melatonin secretion and levels throughout the body begin to rise.*

Melatonin, due to its considerable lipophilicity, is able to cross any cell membrane and enter any tissue or cellular compartment. Therefore it is likely that some of melatonin’s biochemical effects are elicited through intracellular binding sites in addition to its interactions with membrane-bound receptors (Hardeland, 95).

Melatonin’s high lipophilicity is what allows it to transmit the signal of darkness to every cell in the body, in turn acting as the eyes for each cell, organ and tissue. This is why melatonin levels throughout the body are so important for promoting calm, restful sleep and a relaxed mood in the evening by supporting natural circadian rhythms.*

In addition to its effects on sleep, Melatonin is believed to play a major role in the biological termination of free radical induced redox reactions.* Melatonin is reported to have a large capacity to trap hydroxyl radicals, the free radical species with the highest relative reactivity. Melatonin also efficiently traps peroxyl radicals and superoxide anions. Melatonin participates in a two-step process in which it first interacts with a hydroxyl or peroxyl radial to give a melatonyl cation radical, which then combines with a superoxide anion to neutralize the electrical charges and pairing electrons.*

INDICATIONS
Occasional sleeplessness can affect anyone - young or old. The National Institutes of Health recommends keeping a regular schedule of going to bed and waking up at the same time every day, even on weekends, to help your body maintain a normal circadian rhythm. However, due to life’s demands this is not realistic for many people. Endogenous melatonin is an important component of your body’s circadian rhythm. Supplemental melatonin can provide circadian rhythm support for calm, restful sleep - especially when experiencing occasional sleeplessness or jet lag.* Clients who may not have responded to lower dose melatonin or to other alternatives make viable candidates for exogenous supplementation.*

HOW CLIENTS MAY BENEFIT*

• Although many products and ingredients on the market are currently
  sold for promoting sleep and a relaxed mood in the evening, melatonin is
  the #1 product in terms of clinical testing for efficacy in a wide
  variety of populations.*
• High dose of melatonin for those who may have not responded to lower
  doses or alternative preparations.*
• Those who travel often and experience jet lag can benefit from the
  convenience of taking only one melatonin tablet to promote tranquil
  sleep.*
• Participates in free-radical scavenging to support antioxidant
  action in the brain and across various cellular regions due to its high
  lipophilicity.*
• Suitable for a wide-range of clients due to its free of status for
  yeast, wheat, milk or milk derivatives, lactose, sugar, preservatives,
  soy, sodium (less than 5mg per serving), and artificial color and flavor
  as certified through analysis of raw material specification sheets.
• Finished product is suitable for vegetarians.

CLINICAL EVIDENCE

• The clinical effects of melatonin on sleep latency and duration,
  mood, performance, oral temperature and changes in serum melatonin
  levels were examined in twenty male volunteers. Investigators employed a
  double blind, placebo controlled study utilizing repeated measures,
  within-subjects and a 5×5 Latin square design. Subjects received placebo
  or four different doses of melatonin on five different occasions.
  Statistical analysis revealed that all four melatonin doses had
  significant positive effects on sleep duration, self-reported sleepiness
  and fatigue, oral temperature and sleep-onset latency. The authors
  concluded that melatonin can be a highly potent hypnotic agent.
• To measure the effects of exogenous melatonin on jet-lag due to
  rapid transmeridian translocation, 3mg of melatonin was given to elite
  athletes traveling across multiple time zones. Actograms were
  constructed from sleep log diaries by using the Circadia Data Analysis
  program and statistics were measured by nonparametric repeated-measures
  ANOVA. Positive correlations were found between preflight melatonin
  production rates (measuring 6-sulphatoxymelatonin).

SUMMARY
When it comes to supporting nocturnal sleep patterns, melatonin is the #1 supplement in terms of clinical trials and efficacy.* Melatonin’s ability to interact with membrane-bound receptors as well as intracellular binding sites help translate the message of darkness and sleep to each cell in the body.* Just one tablet can be taken in the evening to help promote a relaxed mood and restful sleep.* Physiologics offers high-quality melatonin that is vegetarian-suitable, free of substantial allergenic materials and dosed at levels consistent with published, clinical research.*

SUGGESTED DOSAGE
For adults, take one (1) tablet, only at bedtime as Melatonin may produce drowsiness, or follow the advice of your health care professional. DO NOT EXCEED 3 MG IN A 24-HOUR
PERIOD. As a reminder, discuss the supplements and medications you take with
your health care providers.